Organometallic Compounds
Medchemexpress LLC (S,R,S)-AHPC-PEG3-NH2 hydrochloride | 2097971-11-2 | MFCD31656714 | >95.0% | 656.23 | C30H46ClN5O7S | 2 G
(S,R,S)-AHPC-PEG3-NH2 hydrochloride is a VHL E3 ligase ligand-linker conjugate supplied as the hydrochloride salt for use in PROTAC development and related chemical biology research. It is a PEG3-linked derivative of the AHPC VHL ligand and is provided in multiple packaged sizes for synthesis and assay workflows.
- VHL E3 ligase ligand-linker conjugate suitable for PROTAC design.
- Provided as the hydrochloride salt for improved solubility and handling.
- Available in multiple sizes, including 2 G.
- Molecular formula C30H46ClN5O7S; molecular weight 656.23.
- Purity ≥95% by supplier specification.
Medchemexpress LLC N-(Boc-PEG3)-N-bis(PEG2-alcohol) | 2055042-60-7 | C25H52N2O11 | 50 MG
N-(Boc-PEG3)-N-bis(PEG2-alcohol) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that contain two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Azide-PEG5-Boc | 1415800-41-7 | C17H33N3O7 | 100 MG
Azide-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is a click chemistry reagent containing an Azide group, capable of undergoing copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc)
- Compatible with molecules containing Alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Compatible with molecules containing DBCO or BCN groups
Medchemexpress LLC Ms-PEG5-t-butyl ester | 870487-48-2 | C16H32O9S | 25 MG
Ms-PEG5-t-butyl ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are molecules that contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for a target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PROTAC linker
- PEG-based structure
- Target PROTACs
- Pathway PROTAC
- Used in the synthesis of PROTACs
Medchemexpress LLC Folate-PEG3-C2-acid | 97.6% | 644.63 g/mol | C28H36N8O10 | 10 MG
Folate-PEG3-C2-acid is the acid fragment of a folate-PEG3-based NHS ester and serves as a PEG-type PROTAC linker building block used in the synthesis of PROTAC molecules and folate-conjugated ligands for receptor-targeting studies.
- Purity: 97.6%.
- Molecular weight: 644.63 g/mol.
- Solubility: soluble in DMSO at 33.33 mg/mL (51.70 mM); ultrasonication and heating may aid dissolution.
- Storage: store at 4°C protected from light; in solvent keep at -80°C (6 months) or -20°C (1 month), protected from light.
- Physical state: light yellow to yellow solid.